Post Translational Modification. Post-translational modification PTM refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis. Post-transcriptional modification or co-transcriptional modification is a set of biological processes common to most eukaryotic cells by which an RNA primary transcript is chemically altered following transcription from a gene to produce a mature functional RNA molecule that can then leave the nucleus and perform any of a variety of different functions in the cell.
101002ange201611750 Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6 Anass Chiki Sean M. Post translational modifications refer to any alteration in the amino acid sequence of the protein after its synthesis. Watch this video.
Post-translational modifications can occur on the amino acid side chains or at the proteins C- or N- termini.
For example many proteins are modified shortly after translation is completed to mediate proper protein folding or stability or to direct the nascent protein to distinct cellular compartments eg nucleus membrane. Translation is the synthesis of protein from an mRNA template This process involves several key molecules including1. Post-translational modifications such as glycosylation phosphorylation and sulfation to name a few serve many functions. Post-translational Modifications is a biochemical mechanism in which amino acid recidue in proteins are covalently modified.
